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Phentermine carries its own safety profile: it is a controlled substance approved only for short-term use (12 weeks or less) and is contraindicated in patients with uncontrolled hypertension, coronary artery disease, or history of substance abuse

Halloum W, Dughem YA, Beier D, Pellesi L (2024) Glucagon-like peptide-1 (GLP-1) receptor agonists for headache and pain disorders: a systematic review

Key findings include: (1) Diverse Mechanisms : Plants like cinnamon (cinnamaldehyde), bitter melon (karavilagenine E), and ginseng (ginsenosides) modulate GLP-1 via DPP-4 inhibition, receptor activation, and SCFA production, offering multi-targeted effects beyond glucose control