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on 50 participants with diabetic nephropathy, CoQ10 supplementation 100 mg/day for 12 weeks caused a decrement in serum insulin levels, homeostasis model of assessment-estimated insulin resistance, homeostasis model of assessment-estimated B-cell function, plasma malondialdehyde (MDA), and advanced glycation end product (AGE) levels promoting endothelial health by improving endothelial function, enhancing nitric oxide production, and reducing oxidative stress in blood vessels, supporting proper renal blood flow, vascular health, and kidney function [17,18]

In the realm of natural compounds, biochanin A (BCA), extracted from Astragalus, protects against bone loss by inhibiting TfR1 and enhancing FPN, thereby reducing intracellular iron levels

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