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The NEJM authors reported the most common side effects as mild-to-moderate gastrointestinal events, with the trial discontinued due to adverse events in 4.4% to 7.8% of participants receiving orforglipron compared to 1.4% given the placebo

We are not recommending supplements as a replacement for whole foods, but as a flexible, low-lift option when chewing a full portion of chicken (or even eggs) feels impossible

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Stress can also contribute to mast cell degranulation, which causes them to release mediators like histamine.20 It only makes sense, then, for patients with MCAS to minimize stress as much as possible