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They show two snapshots separated by months, stripped of context, stripped of the nausea that hit at week three, the energy surge at week six, the moment you realized your relationship with food had fundamentally changed

(14) These emerging connections between GLP-1 signaling and skeletal physiology present a biologic rationale for how GLP-1 receptor agonists have potential to not only assist in weight management, but also favorably influence bone health and remodeling

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Furthermore, the overall safety profile was consistent with that of other GLP-1 receptor agonists. As part of the PIONEER 8 trial, Zinman and colleagues randomly assigned a daily regimen of 3 mg oral semaglutide (Rybelsus, Novo Nordisk), 7 mg oral semaglutide, 14 mg oral semaglutide or placebo to 731 adults with type 2 diabetes who were already using insulin (mean age, 61 years