53,54,55 These niche changes include increased expression of inflammatory cytokines such as CXCL14 and cell cycle inhibitors such as CDKN1C and CDKN2A, coupled with downregulation of ECM and adhesion genes, including CAV1 , SPRY1 , FN1 , and ITGB1
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Ozempic injection is also approved to reduce the risk of worsening kidney disease, kidney failure (end-stage kidney disease) and cardiovascular death in adults with type 2 diabetes and chronic kidney disease
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